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Research Evidence For Hypoglycemia – Part 1 (A-B)

By Jurriaan Plesman, BA(Psych), Post Grad Dip Clin Nutr

Always also check  INDEX of Specific Topics and Research and  References for Mood Disorders and Nutrition

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Comments: ‘Hypoglycemia’ is not a medically recognized term, except in connection with diabetes and various other diseases. Doctors appear to be in denial about the significance of hypoglycemia in relation to many illnesses, probably due to the fact that it can be treated without recourse to drugs.

See “Hypoglycemia” by Marilyn Light. It is a popular term used by people with hypoglycemic symptoms as a result of unstable blood sugar levels, and often seen in a special Glucose Tolerance Test. It is now generally accepted that it is the forerunner of diabetes. (See R. Cosford —> page 2) See also: Hypoglycemia: an unnamed medical condition. When it comes to mood disorders, there are many other silent diseases that have an influence on our mind. Both hypoglycemia and diabetes share Insulin Resistance and so if you want to do research into non-diabetic hypoglycemia, you need to look for medical terms such as ‘insulin resistance’, ‘hyperinsulinism’, Glucose Intolerance, hyperglycemia, HPA (hypothalamus-pituitary-adrenal axis), metabolic syndrome, cerebral glucose metabolism. Some scientists studying schizophrenia have already come up with terms such as ‘Cerebral diabetes’, ‘brain diabetes’, pointing to abnormal glucose transport systems across the membranes of brain cells. This comes very close to what we understand hypoglycemia to be, but we would prefer Dr George Samra’s definition of ‘Cerebral Hypoglycia‘, in his book: The Hypoglycemic Connection II, which more accurately points out the importance of glucose transport into cell, including brain cells. Other terms used and that points to hypoglycemia are Syndrome X, Syndrome W. It is to be expected that the medical science will soon recognize ‘hypoglycemia’, although this term may not be used. Until such time when medical scientists can agree on a common term, we will be using the popular term ‘hypoglycemia’. The point is that ‘hypoglycemia’ is a real disease and is forgotten by the medical profession. It is very difficult to research a disease, that ‘doesn’t exist’. The scarcity of research into hypoglycemia is due, no doubt, to the fact that most medical research is carried out by global pharmaceutical companies with an eye on profits for their investors. The financial reward for the production of xenobiotic chemical agents cannot be matched by scientific research about nutritional influences on disease and mental disorders without a ‘profit’ component. For a critical view of the benefits of pharmaceuticals on our health see: Death by Medicine by Gary Null et als.

There is little money to be made from Nutritional Medicine by doctors, because nutrients cannot be patented. There has been much reluctance by the Medical Profession to reward doctors for non-drug therapy based on Clinical Nutrition. We as a Association will continue to support those doctors who have a professional interest in holistic medicine. Below is just a small sample of the research carried out on topics under major headings in alphabetical order which has a bearing on hypoglycemia and Clinical Nutrition. It should also be remembered that hypoglycemia is one aspect of a much wider cluster of symptoms relating to degenerative diseases in general. Thus the net may be cast wide. Because hypoglycemia shares with diabetes “insulin resistance”, much of the research findings concerning diabetes applies equally to hypoglycemia, but the reader should keep in mind the differences between the two, when assessing the data. The under-mentioned references will be updated from time to time. You can search topics in alphabetical order or finding a term by means of “FIND”. [Ctrl+F+"Term"] For more research notes —> here.

ACUPUNCTURE FOR DEPRESSION: Following treatments specifically designed to address depression, 64% of the women (n = 33) experienced full remission.  Source. Acupuncture helps to treat hot flashes in women. Mercola.com

Addiction and Hypoglycemia See; AlcoholismDrug Addiction

ADENOSINE TRIPHOSPHATE (ATP) or biological energy, is closely related to motivationsee here. “An inadequate supply of ATP would result in an inadequate supply of the cAMP required for the phosphorylation of tryptophan hydroxylase into serotonin.” Neuropeptides and supplement  See also Brain & Sugar

ADRENALINE “Adrenaline, secreted by the medulla of the adrenal gland, is carried by the blood to the liver, where it stimulates the breakdown of glycogen to glucose, thus increasing the blood sugar levels” Lehninger 346 See: Adrenaline to Glucose image. ” Normal blood level is 0.06µg/L but when an animal is aroused and galvanized into readiness to fight or flee, adrenaline concentration in blood may increase to almost thousandfold in seconds or minutes.” Lehninger, 728 “During the dynamic phase of Hypoglycemia in response to the rapidly falling blood sugar, serum adrenaline levels rises. This physiological mechanism is involved in increasing serum glucose by promoting gluconeogenesis, i.e., new glucose formation and glycogenolysis whereby glucose is freed from liver stores.”  During a hypoglycemic dip the brain is starved of glucose its only source of energy. This triggers the release of adrenaline and cortisol replenishing the brain with glucose (energy) again. These stress hormones become symptoms of most mood disorders.     Samra, 25, See Adrenaline Synthesis , See also: Adrenal System and overall health.

AGRICULTURAL REVOLUTION: “Since the 1960s the ‘green revolution’ has increased crop yield, and has also accelerated the exodus of hundreds of millions of farmers and their families from the land into lives of misery in mega-cities.” Cannon G 2002,

ALCOHOLICS ANONYMOUS (AA)(12 Steps): “Research indicates that participation in Alcoholics Anonymous and in 12-step treatment are associated with significant reductions in substance abuse and psychiatric problems.” Humphreys K 2003, “There were, however, some indications that bipolar patients functioned at a better level during the follow-up period, particularly those who were older, had a previous history of longer periods of abstinence, and maintained more frequent contact with Alcoholics Anonymous (AA) and their family doctor.” O’Sullivan K, et als. 1998, “God belief appears to be relatively unimportant in deriving AA-related benefit, but atheist and agnostic clients are less likely to initiate and sustain AA attendance relative to spiritual and religious clients. This apparent reticence to affiliate with AA ought to be clinically recognized when encouraging AA participation.” Tonigan JS, et al. 2002, “The purpose of this study was to assess the relationship between attendance at meetings of Alcoholics Anonymous (AA) and follow-up status in a sample of prison inmates.[It was found] the most severe alcoholics were the best AA attenders.” Seixas FA, et als. 1988, “When a person is preoccupied with sex and continues to engage in compulsive sexual activity despite adverse consequences (eg, loss of marriage, job, health, freedom), he or she is a sex addict. Preferred treatment includes professional counseling and attendance at self-help programs based on the Alcoholics Anonymous model.” Schneider JP. 1991, A new concept of  Higher Power Concept in AA.

ALCOHOLICS IN RECOVERY: Comorbid depression appears to be a significant risk factor for relapse among recovering alcoholics. Nutritional therapy + Psychotherapy may prevent relapse. “Of 72 alcoholics who had abstained for a mean of 64 months, 15% had serious, debilitating depressive symptoms, which had begun after a mean of 35 months of sobriety.” Behar D, et als. 1984, “There were, however, some indications that bipolar patients functioned at a better level during the follow-up period, particularly those who were older, had a previous history of longer periods of abstinence, and maintained more frequent contact with Alcoholics Anonymous (AA) and their family doctor.” O’Sullivan K, et als.1988 “Depression was prominent among 40 alcoholics in an alcohol treatment program. Untreated depression may increase risk for relapse to problem drinking.” Lippmann S, et als. 1987, “Sleep variables, anxiety, and depression are considered as possible markers of relapse in persons treated for alcoholism.” Mackenzie A, et als. 1999, “We conclude that severe trait anxiety persisting after 3 weeks of abstinence, comorbid depressive and/or anxiety disorders, and combinations of these with moderate or severe current anxiety and depressive states represent the greatest risks of relapse and therefore may indicate a treatment need.” Driessen M, et als. 2001, “Alcoholics apprehended drink drivers. Assessment revealed that 91% of the alcohol impaired drivers complained of at least some acute symptoms of depression. However, in total 38% of the sample showed significant signs of a clinical psychiatric syndrome (one requiring intervention or treatment) in addition to alcohol dependence.” Sutton LR. 1994, Depression; “Our results showed that (a) the mild-to-moderately symptomatic participants (BDI = 14-19) at 3 months post treatment were on average 2.9 times more likely than the non depressed to have relapsed across follow-ups, and (b) the severely symptomatic participants (BDI = 20+) at 3 months post treatment were on average 4.9 times more likely to have relapsed across follow-ups.” Curran GM, et als. 2000, “Biochemical mechanisms that may contribute to alcohol craving include the stress response of the hypothalamic-pituitary adrenal axis, the endogenous opiate beta-endorphin system, neurotransmitter synthesis and release, hypoglycemia, and nutrient deficiencies.Patients who received nutrition therapy reported significantly fewer hypoglycemic symptoms, lower sugar intake, less alcohol craving as well as significantly greater nutrient intakes; a greater number abstained from alcohol. These findings indicate that nutrition therapy can aid in the recovery from alcoholism.” Biery JR, at als. 1991,

Also read   How to detox from alcohol

Alcoholism: Recovery rate: “Today, everyone in the industry concedes that conventional treatment offers, at best, only a 30 percent success rate. While few major independent studies agree the success rate is that high and more than 600 studies have consistently shown the success rate to be substantially lower (18 percent at six months and less than 10 percent at five years), this has not deterred the treatment industry from proclaiming that treatment works.” Source. See also Drug Addiction recovery rate below. Source including a list showing 10 studies at St. Jude Home Recovery, Amsterdam. “A 1980 Rand Corporation study confirmed earlier research which found that the addictive population studies, once sober, or “clean”, had less than a 15 to 20% rate of continued abstinence.” Strohecker 487 See also: Psychotherapy Ineffective? See also: A.Orange

ALCOHOLISM: ( —-> Drug Addiction) Alcoholism associated with Hypoglycemia Virkkunen M, Kallio E, et al 1994    Consumption of alcohol can trigger hypoglycemia (texaschic) Larry Hoover A good article explaining the relationship between hypoglycemia and alcoholism is by healthrecoverycentre. “Based on results of this study and evidence from the literature, it is suggested that chronic alcoholism is diabetogenic in susceptible individuals and that the transient carbohydrate intolerance found in our study represents and early step in the development of adult-onset diabetes eventually developing in a significant number of chronic alcoholics.” Sereny G, Endrenyi L. 1978, “Intravenous glucose tolerance tests were given to 31 nondiabetic alcoholics and 11 healthy nonalcoholic controls. In almost half of the alcoholics peak glucose concentration was higher and glucose elimination from the plasma was slower than in the controls.” Sereny G, Endrenyi L, Devenyi P. 1975, “It was concluded that glucose intolerance in alcoholic patients is a common finding that occurs in the presence or absence of liver damage.” Iturriaga H, et als. 1986, “These findings indicate that glucose metabolism in alcoholics in a withdrawal state can be disturbed by impaired insulin secretion and insulin resistance.” Adner N, Nygren A. 1986,

Alcohol dependency is accompanied by zinc content decrease in the hippocampus Bovt VD, 2001. Aboriginal populations in Australia have been found to be zinc deficient. This could be a factor in alcoholism found among the Aborigines. Cheek 1981, & Cheek 1981 (A), Holt AB et als 1980, Zinc administration improves gastric alcohol dehydrogenase activity in alcoholics, rat model, Caballeria J, 1997 Alcoholics may be deficient in zinc, an essential coenzyme in alcohol dehydrogenase. Bahmer 1981, Lorentzen HF 2000, Menzano E et als 1994, Prasad AS 1991, See Zinc “The synthesis of serotonin involves Zn [zinc] enzymes and since serotonin is necessary for melatonin synthesis, a Zn deficiency may result in low levels of both hormones. Zn levels tend to be low when there is excess Cu and Cd. Moreover, high estrogen levels tend to cause increased absorption of Cu and Cd, and smoking and eating food contaminated with Cd result in high levels of the latter. Furthermore, ethanol ingestion increases the elimination of Zn and Mg (which acts as a cofactor for CuZnSOD)[superoxidedismutase]” Johnson S. 2001 “Alcoholism impairs zinc absorption and increases zinc loss via urine” Milne DB et al (1993) A case study of an alcoholic with severe long-term hypoglycemia: “The probable etiology of low blood sugar in our patient was alcohol-induced inhibition of gluconeogenesis along with starvation. The prolonged hypoglycemia caused cortical damage simulating ischemic brain damage. Ten months in to follow-up patient is still in persistent vegetative state with no noticeable neurological recovery.” Jain H, et als. 2002, “acute alcohol consumption brings on hypoglycemia in many individuals, since it inhibits gluconeogenesis from lactate and amino acids” Lehninger, 762 Hypoglycemia may be antecedent: “The origin of this atypical blood glucose response may antedate the onset of alcoholism, or it may be secondary to alcohol-related damage that persists beyond 6 months. Previous accounts of increased sweet consumption in alcoholics were not substantiated, although they may be present in the peri-withdrawal period.” Umhau JC, et als. 2002, Alcoholics are found to be vitamin C deficient. For more studies about association between violence, alcoholism, blood sugar levelhere.

Alcoholism Statistics: Approximately 4% of adult drinkers are alcoholics, a figure calculated from the known incidence of mortality caused by cirrhosis of the liver, and therefore probably a conservative estimate. International comparisons of alcoholism generally rely on data on cirrhosis of the liver (the “Jellinek formula”), and it is known that cirrhosis rates are highly correlated with overall consumption levels. Therefore, rates of alcoholism for the countries of the world generally reflect consumption levels, so alcoholism in Canada is about average for Western countries. About 2200 persons annually die in Canada from cirrhosis of the liver, which is equivalent to a death rate per year of 8.0 per 100 000 population. A few hundred more die of other alcohol-related conditions (poisoning, automobile accidents, etc). Rates of death caused by cirrhosis of the liver increase markedly with age and are higher in urban areas and in the west and north, the areas with the highest levels of alcohol consumption in Canada.   Wikipedia: The World Health Organization estimates that there are 140 million people with alcoholism worldwide.[4][5]

The 2006 survey indicated very little change in drinking habits, with about half of the population (50.9 percent) reported as alcohol drinkers, about one-fifth binge drinkers and about seven percent listed as heavy drinkers. Source “Estimates vary, but recent studies  at UCLA show that “the top 5% of drinkers account for 42%of the nation’s total alcohol consumption.” If 5% of all drinkers account for nearly half of total alcohol sales, it would be folly for the alcohol industry to get serious about encouraging moderation. ” Addiction Inbox

 ALCOHOLISM AND GENETICS: Scientists have found that alcoholics appear to metabolize a break-down product of alcohol (acetaldehyde) in a different way from non-alcoholics. This appears to be due to a mutation in the gene affecting the action of an enzyme. Small amounts of acetaldehyde in combination with some neurotransmitters (serotonin and dopamine) are converted to tetrahydroisoquinoline (THIQ), an opiate-like substance, rendering the person very sensitive, tolerant and addictive to alcohol. Another enzyme, Fyn tyrosine kinase, has also be implicated in sensitizing individuals to alcohol. However a recent study appear to dispute this. See for an explanation Cowen MS et als. 2003, See also Diabetic gene (s)

ALCOHOLISM AND VIOLENCE: “Based on clinical observations in a series of studies on Finnish alcoholic, violent offenders, we asserted that the impulsive offenders represented an extreme group of type 2 alcoholics. We also observed that these subjects were vulnerable to hypoglycemia after the administration of oral glucose load. Furthermore, we believe that while being hypoglycemic, the impulsive offenders are particularly irritable and aggressive.” Virkkunen M, Kallio E, Rawlings R, et als. 1994, “Partner violence is a serious problem for women in alcoholism treatment.” Chase KA, et als. 2003, “The odds of severe male-to-female physical aggression were more than 11 times (11 times) higher on days of men’s drinking than on days of no drinking. These findings support the proximal effect model of alcohol use and partner violence.” Fals-Stewart W. 2003, “A defect in central serotonin metabolism may manifest itself in poor impulse control leading to attempts at suicide, violence towards others, and Type II alcohol abuse. We also studied pathological gamblers. They showed significantly increased central noradrenaline metabolism, perhaps related to sensation seeking.” Roy A, Linnoila M. 1989, See also: Violence and Aggression

ALLERGIES: A good book is; Samra G (2003), THE ALLERGY CONNECTION; Food and Disease Paradigm. See also: Allergies: The Food and Disease Paradigm by Dr George Samra “…the proportion of the persistent young offender population with maladaptive behaviours linked to food allergy, food intolerance and nutritional problems is cautiously estimated to be 75% whereas 18% of the young non-offender population is similarly affected. C Peter et als. 1997

ALOE VERA: beneficial in diabetes. 5 patients with type II diabetes given the dried sap of aloe (1/2 tsp daily) experienced a reduction from mean glucose level 273 to 151 mg/dl (15 mmol/L to 8.4 mmol/L), including a study with diabetic mice. Gannam, N 1986,

ALTERNATIVE MEDICINE: There is evidence of of increasing use of alternative or complementary medicine: de Visser et al 2002, Eisenberg et als 1998, Fautrel B et als 2002,  Feldman, RH & Laura R, 2004, Ramel B 2002, Sagaram et als 2002, Alan Bensoussan, Wikepedia

ALTERNATIVE SWEETENERS: There is a lot of information on the internet, some of it rather controversial. The American Diabetic Association has this to say. But see the numerous articles about the symptoms of aspartame. We recommend Stevia as a very safe alternative sweetener. See also Xylitol.   See also erythritol a fairly safe sweetener in addiction to stevia and xylitol Wikipedia See also Herbs with Hypoglycemic Effects. See also article on sweeteners by Sue Litchfield here and go to page 2.

ALZHEIMER‘S DISEASE: For a connection between insulin resistance and Alzheimer’s Disease. —> Imagawa M, et als 1992, Craft S et als 1996, Holden RJ et al, 1995, Watson GS, et als 2003, Ronnemaa E et als. (2008) Five more studies. And here For Nutritional Treatment  Its aluminium connection not proven. Storey E, et al. 1995, See also here. For insulin receptors in the brain, Werther GA, et als. 1987, Diabetes poses a greater risk , Frey J 2001, Prediabetes (Hypoglycemia)  linked to Alzheimer’s Disease See also Hypoglycemia and dementia.

Alzheimer’s Cases to Triple by 2050   09/12/2013 10:09 AM EDT Source: Fisher Center for Alzheimer’s Research Foundation.

See: Memory and Coconut Oil

Antioxidant-Rich Diet May Not Reduce Dementia Risk 09/12/2013 10:09 AM EDT Source: Fisher Center for Alzheimer’s Research Foundation.

Breast cancer Treatment by Prof Jane Plant Phd, CBE

Diabetes Drug Metformin may reduce risk of dementia:  MONDAY, July 15 (HealthDay News) — The diabetes drug metformin may do more than help control blood sugar levels: New research suggests it may also reduce the risk of dementia. Compared to people taking another class of diabetes medications called sulfonylureas, those taking metformin had a 20 percent reduced risk of developing dementia over the five-year study period. MedlinePlus 15 July 2013 Alzheimer’s disease discussed by Dr Chris Reading

“The human brain uses glucose as a primary fuel; insulin secreted by the pancreas cross the blood-brain barrier (BBB), reaching neurons and glial cells, and exerts a region-specific effect on glucose metabolism. Glucose homeostasis is critical for energy generation, neuronal maintenance, neurogenesis, neurotransmitter regulation, cell survival and synaptic plasticity. It also plays a key role in cognitive function. In an insulin resistance condition, there is a reduced sensitivity to insulin resulting in hyperinsulinemia; this condition persists for several years before becoming full-blown diabetes. Toxic levels of insulin negatively influence neuronal function and survival, and elevation of peripheral insulin concentration acutely increases its cerebrospinal fluid (CSF) concentration.

Peripheral hyperinsulinemia correlates with an abnormal removal of the amyloid beta peptide (Abeta) and an increase of tau hyperphosphorylation as a result of augmented cdk5 and GSK3beta activities. This leads to cellular cascades that trigger a neurodegenerative phenotype and decline in cognitive function.”Neumann KF et als (2008), Insulin resistance and Alzheimer’s Disease. See For 8 PubMed Studies High Blood Sugar May Add to Alzheimer’s Risk  05/08/2013 04:00 PM EDT  Brain scans suggest possible link between the two  Two PubMed Studies linking Alzheimer’s Disease to insulin resistance.

  • Insulin Resistance (Hypoglycemia) increases risk for Alzheimer’s Disease.
  • Plays a role in cognition and other degeneratve diseases
  • Potential mechanism of increased risk: Effects of inflammation and  β-amyloid
  • Therapeutic applications: Effects of treating insulin resistance and normalising CNS insulin. in relation with trials rosiglitazone. Department of Veteran Affairs and GlaxoSmithKline.

One in three seniors die from Alzheimer’s disease– There’s more troubling news for America’s aging population: A new report finds that one in every three seniors now dies while suffering from Alzheimer’s or another form of dementia.  In many cases, dementia is the cause of death or contributes to it, the Alzheimer’s Association study finds. Source AD patients are deficient in acetylcholine. See also:  Alzheimer Update 2012 and here.

Curcuminoids from Curcuma longa L. (Zingiberaceae) that protect PC12 rat pheochromocytoma and normal human umbilical vein endothelial cells from betaA(1-42) insult. Kim DS, Park SY, Kim JK. Neurosci Lett. 2001 Apr 27; 303(1):57-61.  PMID: 11297823 Protective effect of Rosa laevigata (Cherokee rose) against amyloid beta peptide-induced oxidative stress. Choi SJ, Kim MJ, Heo HJ, Kim HK, Hong B, Kim CJ, Kim BG, Shin DH. Amyloid. 2006 Mar; 13(1):6-12. PMID: 16690494

Gingko may be positive for Alzheimers’s disease Weinmann 2010, Kasper 2009 go to URL, but other studies show it to be ineffective. See also: Brigitte Grass-Kapanke et als. (2011) Certain Chinese herbs including Panax ginseng may have potential therapeutic effects or Alzheimer’s Disease.  PMID: 12725562  For more studies on Alzheimer’s Disease —> Alzheimer’s Disease

High Blood Pressure tablets may be protective against Alzheimer’s Disease

ANHEDONIAis an inability to experience pleasure, including in sexual orgasm. It appears it can be reversed by fluoxetine in some cases – an SSRI – indicating that it may be due to a serotonin deficiency. It is associated with some ‘mental’ illnesses such as anxiety, depression, bipolar disorder and schizophrenia. Anhedonia associated with depression. Further References. For more information see: Anhedonia, Anhedonia related to clinical depression and insulin resistance. Ian H Gotlib et al. 20

ANTIBIOTICS & BLOOD SUGAR LEVELS:   THURSDAY, Aug. 15 (HealthDay News) — Diabetes patients who take a certain class of antibiotics are more likely to have severe blood sugar fluctuations than those who take other types of the drugs, a new study finds. The increased risk was low but doctors should consider it when prescribing the class of antibiotics, known as fluoroquinolones, to people with diabetes, the researchers said. This class of antibiotics, which includes drugs such as Cipro (ciprofloxacin), Levaquin (levofloxacin) and Avelox (moxifloxacin), is commonly used to treat conditions such as urinary tract infections and community-acquired pneumonia. philli.com 15 Aug 2013

ANTIPSYCHOTIC MEDICATIONS: Significant weight gain experiences in children using anti-psychotic drugs, such as olanzapine (Zyprexa), ariprazole (Abilify), quetiapine (Seroquel) or resipiridone (Risperdal). Science Update Oct 2009

AMA Statement on Hypoglycemia in 1973   Because of the possible misunderstanding about the matter, three organizations of physicians and scientists (the American Diabetes Association, the Endocrine Society, and the American Medical Association) have issued the following statement for the public concerning the diagnosis and treatment of hypoglycemia: Published 5 February 1973, Statement on hypoglycemia, editorial. JAMA 223:682, 1973  (JAMA. 1973 Feb 5;223(6):682. PMID:4739198)

“Hypoglycemia means a low level of blood sugar. When it occurs, it is often attended by symptoms of sweating, shakiness, trembling, anxiety, fast heart action, headache, hunger sensations, brief feelings of weakness, and, occasionally, seizures and coma. However, the majority of people with these kinds of symptoms do not have hypoglycemia; a great many patients with anxiety reactions present with similar symptoms. Furthermore, there is no good evidence that hypoglycemia causes depression, chronic fatigue, allergies, nervous breakdowns, alcoholism, juvenile delinquency, childhood behavior problems, drug addiction or inadequate sexual performance. . . .” Atkinsexposed.org See also here and here.

ANXIETY & PANIC ATTACKS: Anxiety & “REACTIVE HYPOGLYCEMIC” PROCESSING: Consume excessive sugar food or beverage; pancreas dumps excess insulin (remember ADAPTION); About two hours later blood sugar crashes to emergency level; adrenal gland dumps excess adrenaline (remember ADAPTION); RESULT=ANXIETY and HORMONAL IMBALANCE” Professor Joel H. Levitt.  See also: Anxiety Attacks explained by Gary Null

There is a significant association between anxiety attacks and hypoglycemia according to these sources and here. See also:  Anxiety Attacks and Reactive Hypoglycaemia Youtube Clinical anxiety may be associated with an elevated blood lactate level and increased lactate to pyruvate ratio. (Buist RA, Anxiety Neurosis: The lactate connection, Int Clin Nutr Rev 5(1): 1-4, 1985) “The lactate to pyruvate is increased by alcohol, caffeine and sugar, and decreased by deficiencies of niacin, thiamine and magnesium. While more studies are needed, it appears that normalizing an elevated blood lactate level will sometimes relieve anxiety”, Werbach, 1991, 48, Low levels of phosphorus (hypophosphatemia) may be associated with anxiety, irritability, numbness, paresthesia (subjective feelings, numbness, ‘pins and needles’) no abstract, mentioned in Werbach 1991, 53 A good web site dealing with the connection between anxiety and hypoglycemia is at Sweet Nothings.

APPLE CIDER VINEGAR: is fermented form crushed apples alcohol into acetic acid-forming bacteria into vinegar. “This small study shows that vinegar delays gastric emptying in insulin-dependent diabetes mellitus patients with diabetic gastroparesis. Clearly, a larger, randomized trial involving a greater number of patients would be needed to validate the findings of this pilot study.” Hlebowicz J et als.(2007) Popular home remedy for allergies, sinus infections, acne, high cholesterol, flu, chronic fatigue, candida, acid reflux, sore throats, contact dermatitis, arthritis, osteoporosis, blood pressure, gout. It assist in stimulating digestion and is said to help in weight control. Source.

ARSONISTSmay be hypoglycemic Virkkunen M 1984

ATHEROSCLEROSIS & HYPOGLYCEMIA: HYPONLDEC97 and go to page 6 “All of those dysfunctions together with hyperinsulinism can greatly enhance the risk of atherosclerotic vascular disease.” Nunes JS, et als. 2000, See also: Yourhealth.com

ATTENTION DEFICIT AND HYPERACTIVITY (ADHD) DISORDER: Lendon Smith‘s article about the non-drug treatment of ADHD. See also  Lendon Smith article in Hypo Newsletter —> page 12 Hyperactive children will benefit from a hypoglycemic and allergies free diet, with specific supplements such as B-Complex vitamins, Vitamin C and proanthocyanidins, fish oil containing DHA, zinc, magnesium and digestive enzymes Maria Zimmerman,

“ADHD was highly prevalent among obese patients and highest in those with extreme obesity. Comorbid obesity and ADHD symptoms rendered treatment less successful compared to NAD counterparts. Reasons for the comorbidity are unknown, but may involve brain dopamine or insulin receptor activity. If replicated in further studies, these findings have important implications for treatment of severe and extreme obesity.” Altfas JR. 2002, But see  Obesity Controversy.   Also see Hyperactivity . Also Look up “Probiotics“.

AUTISM may be linked to GI problemsInducing, Augmenting Labor May Be Tied to Autism 08/12/2013 03:06 PM EDT Children of women who had labor induced or sped up with drugs were more likely to go on to develop an autism spectrum disorder, in a new study. Faulty enzymes linked to autism. See also Autism at Index.

AVOCADO EXTRACT: “The article suggests controlling blood glucose sugar levels in order to “help starve the cancer and bolster the immune system.” It also suggests that mannoheptulose, a purified avocado extract, may help. Researchers at Britain’s Oxford University Department of Biochemistry found that mannoheptulose inhibits tumor cell glucose uptake and also inhibits glucokinase, the enzyme used in glycolysis. In laboratory tests, mannoheptulose inhibited growth in cultured tumor cells as well as reducing tumor size in animal subjects.” Townsend Letter June 2002, “Partial replacement of complex digestible carbohydrates with monounsaturated fatty acids (avocado as one of its main sources) in the diet of patients with non-insulin-dependent diabetes mellitus improves the lipid profile favorably, maintains an adequate glycemic control, and offers a good management alternative.” Lerman-Garber I, et als. 1994,

BENIGN PROSTATIC HYPERPLASIA: For years, men with enlarged prostate glands have turned to a supplement called saw palmetto to ease their trouble with urination and other symptoms. Exactly how saw palmetto was thought to relieve the symptoms is unclear, but the fruit of saw palmetto dwarf palm tree remains widely used. Now, a new study shows that this popular remedy is no more effective than a placebo or dummy pill at relieving these symptoms — even in high doses.The study is published in The Journal of the American Medical Association. WebMd Newsletter 28 July 2012

BILBERRY: see Diabetic Retinopathy.

BIPOLAR DISORDER: —> For more information see Alternative Mental Health go to “articles”, See also Lithium Carbonate. “Glucose utilization, serum insulin, human growth hormone, and free fatty acids were studied in 18 unipolar depressed patients and 14 normal controls, using the intravenous glucose tolerance test. [But] endogenous depression was associated with lowered glucose utilization rate with insulin resistance.” Wright JH, et als. 1978, A case study of a bipolar disorder with a deficiency of folate and vitamin B12 leading to pseudodementia. Reid SD 2000 Omega-3 fatty acids contained in fish oil may benefit people with bipolar disorder. Rudin DO 1981 . There are studies to show that the supplementation with phenylalanine (Precursor of L-tyrosine (amino acids found in food) can benefit Bipolar patients. Phenylalanine with vitamin B6 are the forerunners of phenylethylamine (found in chocolate). Sabelli HC et al., 1986 Misdiagnosis: Between 10 and 30% of depressed patients, mostly bipolar, develop a therapy-resistant illness. The known causes of such chronic evolutions are discussed: Levine S 1986

Bipolar patients can benefit from lecithin, which contains 10-20% phosphatidylcholine, the precursor of the neurotransmitter acetylcholine. 3 PubMed Studies.  Pantothenic Acid (Vitamin B5 required as coenzyme in conversion). It is known to treat mania. Hirsch MJ et als, 1996 Stoll AL, et als 1996 , however this should not be used in the depressive phase of bipolar disease. See also Hypo NL June 2001, Page 10. See also:  Treatment of Bipolar Disorder ‘A double-blind trial found that bipolar patients taking 9.6 grams of omega-3 fatty acids from fish oil per day in addition to their conventional medications had significant improvements compared with those taking placebo” Stoll AL, et als. 1999, Kato 1996 , See also relation between Vanadium & bipolar Disorder. “Polyunstaruted fatty acids in bipolar patients: The major finding was significantly reduced arachidonic acid (20:4n-6) and docosahexaenoic acid (22:6n-3) compositions in bipolar patients as compared to normal controls with P values of 0.000 and 0.002, respectively.” Chiu CC, et als. 2003, “CONCLUSIONS: The results of this study suggest that bipolar disorder is associated with alterations in the metabolism of cytosolic, choline-containing compounds in the anterior cingulate cortex. As this resonance arises primarily from phosphocholine and glycerophosphocholine, both of which are metabolites of phosphatidylcholine, these results are consistent with impaired intraneuronal signaling mechanisms.” Moore CM, et als. 2000,

BIPOLAR DISORDER AND GENES: “Linkage evidence suggests that chromosome 13 (13q32-33) contains susceptibility genes for both bipolar disorder and schizophrenia. Recently, genes called “G72″ and “G30″ were identified, and polymorphisms of these overlapping genes were reported to be associated with schizophrenia. These data suggest that a susceptibility variant for bipolar illness exists in the vicinity of the G72/G30 genes. Taken together with the earlier report, this is the first demonstration of a novel gene(s), discovered through a positional approach, independently associated with both bipolar illness and schizophrenia.” Hattori E, et als. 2003, John Easton. BIPOLAR DISORDER: See: supplements for. E.M. Power+ product for Bipolar Disorder. Kaplan BJ et als. 2001, and PubMed See also Bipolar Disorder at Index.

BITTER LEMON(Mormordica charantia): also known as Balsam pear, Bitter Gourd, Karela is tropical fruit. Glucose tolerance of 73% of the maturity onset diabetic patients improved with fruit juice of M. charantia Welihinda 1986 , but subsequent studies have not supported this. Also Cunnick J et als. J Naturopath Med 4(1): 16-21, 1993, mentioned in Werbach et al. 1994, 130 , The effects are gradual and cumulative.

BRAIN & GLYCOGEN: “The data suggest that brain glycogen can provide fuel for extended periods of time when glucose supply is inadequate. Furthermore, brain glycogen can rebound (super-compensate) after a single episode of hypoglycemia. We postulate that brain glycogen serves as an energy store during hypoglycemia and that it may participate in the creation of reduced physiological responses to hypoglycemia that are involved in a symptom often observed in patients with diabetes, hypoglycemia unawareness” Choi IY, et als. 2003,  See also PMID: 21337590

BRAIN & IT’S INSULIN RECEPTORS: “Insulin facilitates glucose uptake by most tissues including the hypothalamus but not including most parts of the brain. The difference in behaviour is thought to have something to do with the presence of large amounts of neuroglia (supporting structural tissue) found in the hypothalamus. Figure 4 shows how the brain ‘reflects’ blood glucose levels yet the hypothalamus may have different glucose content. This explains why a person with extremely low blood sugar may appear to function near to normal yet another person with slightly higher blood sugar level may be in a hypoglycemic coma.” Samra, 2003, Hypoglycemia… 63 For Insulin Receptors in other parts of the brain and Central Nervous System: see here

BRAIN & SUGAR: “This review focuses on the neurologic issues concerning the treatment of hypo- or hyperglycemia in the critically ill patient. Moderate hypoglycemia may evoke a significant stress response, behavioral changes, and alterations in cerebral blood flow and metabolism. CONCLUSION: Because both hypo- and hyperglycemia may produce neurologic changes, aggressive management of abnormal glucose values is warranted.” Sieber FE, et al. 1992, see also Glucose Glucose have different effects on different parts of the brain. Samra, 2003, Chapter 3 “The glucose solution produced more substantial EEG effects than the other three carbohydrate solutions. Absolute blood glucose level was the primary determinant of electrocortical changes found predominantly in the left parietal-occipital and left temporal cortical regions. Implications for the study and evaluation of cognitive function were discussed.” Fishbein DH, et als. 1990,  Nine studies showing that impairment in mitochondria energy production of ATP from glucose may be a mechanism underlying pathophysiology of psychiatric disorders, like bipolar disorder, depression and schizophrenia. Source. For Glucose requirement of the brain —> Glucose ,


2 Responses

  1. Cassandra Plesman says:

    This is a fantastic read Jur. I would like to know if evening primrose oil could be a substitute for the beneficial effects of fish oil? In your view, what effects does calcium have on the nervous system and how can it affect cardio vascular health?
    Cassandra

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